Last weekend was of the utmost importance for every 2-2 team. The difference between 2-3 and 3-2 might only be a game but each record feels massively different. Now, in Week 6, it's up to those teams that lost to find their footing as we approach midseason.
Week 6 kicks off with a Thursday night showdown between the San Francisco 49ers and Seattle Seahawks. The 49ers are coming off a disheartening defeat to the Arizona Cardinals. Two of the 49ers three losses have come after obtaining big leads. We know Kyle Shanahan has a knack for blowing leads like that, but the 49ers are still Super Bowl hopefuls and need to figure out their issues if they want to compete in the NFC West.
On Sunday, the Jacksonville Jaguars return to London to take on the Chicago Bears. Sunday night will feature Cincinnati Bengals taking on the New York Giants, fresh off a stunning victory over the Seahawks. Then, Monday Night Football will finish the week off with an AFC East showdown between the New York Jets and Buffalo Bills.
Take a look at all the odds and our expert predictions for this week's matchups.
New to sports betting? USA TODAY readers can claim exclusive promos and bonus codes with the best online sportsbooks and sports betting sites. Here are the NFL betting odds for Week 5, according to the BetMGM NFL odds.
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PROP TALK: These are the best prop bets for NFL games this week
NFL Week 6 picks/predictions
Seahawks vs. 49ers
Bears vs. Jaguars
Ravens vs. Commanders
Packers vs. Cardinals
Patriots vs. Texans
Saints vs. Buccaneers
Eagles vs. Browns
Titans vs. Colts
Broncos vs. Chargers
Raiders vs. Steelers
Panthers vs. Falcons
Cowboys vs. Lions
Giants vs. Bengals
Jets vs. Bills
NFL Week 6 point spreads
San Francisco 49ers (-3.5) at Seattle Seahawks
Jacksonville Jaguars (+2.5) vs. Chicago Bears
Washington Commanders (+6.5) at Baltimore Ravens
Arizona Cardinals (+5) at Green Bay Packers
Houston Texans (-7) at New England Patriots
Tampa Bay Buccaneers (-3.5) at New Orleans Saints
Cleveland Browns (+8.5) at Philadelphia Eagles
Indianapolis Colts (-1) at Tennessee Titans
Los Angeles Chargers (-3) at Denver Broncos
Pittsburgh Steelers (-3) at Las Vegas Raiders
Atlanta Falcons (-6) at Carolina Panthers
Detroit Lions (-3) at Dallas Cowboys
Cincinnati Bengals (-3.5) at New York Giants
Buffalo Bills (-2.5) at New York Jets
NFL Week 6 moneylines
San Francisco 49ers (-190) at Seattle Seahawks (+155)
Jacksonville Jaguars (+120) vs. Chicago Bears (-145)
Washington Commanders (+240) at Baltimore Ravens (-300)
Arizona Cardinals (+190) at Green Bay Packers (-250)
Houston Texans (+240) at New England Patriots (-300)
Tampa Bay Buccaneers (-200) at New Orleans Saints (+165)
Cleveland Browns (+350) at Philadelphia Eagles (-450)
Indianapolis Colts (-115) at Tennessee Titans (-105)
Los Angeles Chargers (-165) at Denver Broncos (+140)
Pittsburgh Steelers (-155) at Las Vegas Raiders (+130)
Atlanta Falcons (-275) at Carolina Panthers (+220)
Detroit Lions (-165) at Dallas Cowboys (+140)
Cincinnati Bengals (-185) at New York Giants (+150)
